Ground-based and in-situ studies have been conducted using data from Wallops Island, Virginia,to understand more about midlatitude spread F (MSF). Both ground-based and in-situ studies will be described. The ground-based study includes digisonde data for a complete solar cycle from 1996-2006. Seasonal and solar cycle variations have been studied using the data-set; both are significant, and are somewhat different for range and frequency spread F. Correlations of spread F duration with F10.7, Kp and AE are investigated. The results provide insights into causative sources for both types of midlatitude spread F. The in-situ study includes data from a rocket launched from Wallops Island into a midlatitude spread F condition. The instruments aboard the flight were used to measure the neutral wind, electric field and plasma density in the spread F region. The in-situ measurements show no compelling evidence of small scale plasma density, wind or electric field variations, but do show the signature of a meso-scale gravity wave. The high resolution rocket data are in good agreement with simultaneous datasets gathered by ground-based radars participating in the experiment.